Citation-first clinical tool

AI Renal / Hepatic Dose Adjustment Lookup

The Renal / Hepatic Dose Adjustment Lookup returns the FDA-label and KDIGO-grounded dose bands for a single drug across renal function categories (eGFR or CrCl bands) and hepatic function categories (Child-Pugh A/B/C). Output includes label guidance, monitoring considerations, dialysis considerations where relevant, and the references the clinician should open to confirm. The tool does not recommend a final dose — final dosing remains a clinician and pharmacy decision.

This tool is for educational and decision-support use only. It does not replace independent clinical judgement. Always verify against the current guideline, FDA label, or specialty reference cited below before acting. Do not enter patient identifiers (name, MRN, dates of service).

FDA Drug Label + KDIGO + Sanford Guide (2024) — FDA / KDIGO / Sanford — read source Primary publication: Each response names the specific FDA label and KDIGO publication.

Who this is for

Hospitalists and APPs prescribing renally / hepatically cleared agents
Internal medicine and nephrology trainees
Inpatient and community pharmacists

Frequently asked questions

Does the tool replace the FDA label?

No. It surfaces the label structure for fast review; the clinician should always confirm against the current FDA label before prescribing.

Are dialysis-specific doses included?

Yes when the FDA label or KDIGO provides them. Intermittent vs continuous dialysis often differ; verify with your renal pharmacist.

Is Child-Pugh always applicable?

No. Many drugs have only renal-elimination data and no hepatic-impairment guidance. The tool will note when hepatic data is unavailable.

Can I look up multiple drugs at once?

One drug per request to keep output focused. For polypharmacy, run several lookups or escalate to clinical pharmacy.

What if the FDA label is silent?

The tool will surface that gap, point to alternative references (Sanford, KDIGO, Aronoff), and recommend pharmacy review.

Ask in Rounds

Tool

Who this is for

Frequently asked questions

Related clinical tools