What is the recommended dose and treatment duration of azithromycin for typhoid fever in adults and children? | Rounds What is the recommended dose and treatment duration of azithromycin for typhoid fever in adults and children? | Rounds
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What is the recommended dose and treatment duration of azithromycin for typhoid fever in adults and children?

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Azithromycin Dosing for Typhoid Fever

Azithromycin dosing for typhoid fever in children is recommended as 20 mg/kg/day (oral) for 5–7 days. [1]

In adults, azithromycin regimens studied for uncomplicated typhoid fever include 500 mg (oral) once daily for 7 days. [2]

Pediatric Dose and Duration

  • 20 mg/kg/day (oral) once daily for 5–7 days is recommended for typhoid fever. [1]

Alternative Pediatric Regimen From Clinical Trials

  • 10 mg/kg/day (oral) once daily for 7 days (maximum 500 mg/day) has been evaluated in children with uncomplicated typhoid fever. [3]

Adult Dose and Duration

  • 500 mg (oral) once daily for 7 days has been evaluated in adults with typhoid fever. [2]

Key Dosing Consistency Across Regimens

  • Clinical trials commonly used a once-daily oral azithromycin strategy with 7-day treatment duration for uncomplicated typhoid fever. [2], [3]

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