What is morphine‑6‑glucuronide (M6G)?

Medical Advisory Board
All articles are reviewed for accuracy by our Medical Advisory Board.

Educational purpose only · Not a substitute for professional judgment or the full text of guidelines and labels.

Article Review Status

Submitted

Under Review

Approved

Last updated: July 14, 2026 · View editorial policy

Morphine-6-Glucuronide (M6G)

Morphine-6-glucuronide (M6G) is a major metabolite of morphine formed by glucuronidation in the liver and other tissues. M6G is pharmacologically active and has opioid analgesic effects related to mu-opioid receptor activity. M6G is cleared primarily by the kidneys, so it can accumulate in patients with impaired renal function.

Morphine-6-Glucuronide (M6G)

Related Questions