Intramuscular Vitamin D3 (Cholecalciferol) Dosing Schedule in Adults
Moderate-to-severe vitamin D deficiency in adults can be treated with intramuscular cholecalciferol 300,000 IU given as one or two annual doses. [1]
Treatment Schedule
- 300,000 IU cholecalciferol IM once, with repeat after 12 months if needed, to complete one or two annual doses. [1]
Clinical Context
- This intramuscular high-dose strategy is described as reversing vitamin D deficiency states when given as one or two annual injections of 300,000 IU. [1]
Notes on Formulation and Regimen Design
- Studies comparing high-dose intramuscular cholecalciferol commonly use single large-dose regimens such as 300,000 IU IM in adults with hypovitaminosis D. [2]