Vortioxetine Weight Change
Vortioxetine is not associated with clinically meaningful weight gain in short-term treatment compared with placebo. [1]
Across randomized studies in major depressive disorder, mean body-weight change is small and similar to placebo. [1], [2]
Short-Term Effects on Body Weight
In 6- to 8-week placebo-controlled studies, vortioxetine had no significant effect on body weight versus placebo based on mean change from baseline. [1]
A pooled analysis of short-term trials reported clinically significant weight gain (defined as ≥7% increase from baseline) occurred infrequently, with an incidence of <3% across vortioxetine dose groups. [2]
Long-Term Effects on Body Weight
In a 6-month double-blind, placebo-controlled relapse-prevention phase, there was no significant effect on body weight between vortioxetine- and placebo-treated patients. [1]
In the relapse study, the proportion of patients with weight increases was 6.5% with vortioxetine versus 5.8% with placebo. [3]
Clinical Implication
Overall, vortioxetine demonstrates a low likelihood of clinically significant weight gain relative to placebo in adults treated for major depressive disorder. [1], [2], [3]