What is the maximum safe daily dose of magnesium oxide that an adult can take within a 24‑hour period for dyspepsia or antacid therapy? | Rounds What is the maximum safe daily dose of magnesium oxide that an adult can take within a 24‑hour period for dyspepsia or antacid therapy? | Rounds
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What is the maximum safe daily dose of magnesium oxide that an adult can take within a 24‑hour period for dyspepsia or antacid therapy?

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Magnesium Oxide Antacid (Dyspepsia/Acid Indigestion) Maximum Daily Dose

For oral magnesium oxide 400 mg tablets labeled for antacid use, the maximum labeled dosing is no more than 2 tablets in a 24-hour period. [1]

Maximum Amounts per 24 Hours

  • Maximum magnesium oxide (compound) dose: 800 mg/day (2 × 400 mg tablets). [1]
  • Maximum elemental magnesium dose: 480 mg/day (2 × 240 mg elemental magnesium per tablet). [1]

Additional Safety Labeling

  • Use beyond the labeled maximum dosing duration is restricted: do not use the maximum dosage for more than 2 weeks without clinician supervision. [1]
  • Clinician input is recommended with kidney disease. [1]

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