What is Powassan virus? | Rounds What is Powassan virus? | Rounds
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What is Powassan virus?

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Last updated: July 14, 2026 · View editorial policy

Powassan virus infection

Powassan virus is a tick-borne flavivirus (family Flaviviridae) that can cause neuroinvasive disease such as encephalitis. [1]

Transmission

Powassan virus disease is caused by an infected tick bite, which transmits the virus to humans. [2]

Disease manifestations

Powassan virus disease can present as acute febrile illness with neurologic symptoms such as encephalitis or meningoencephalitis. [3]

Prevention

Prevention focuses on reducing tick exposure through tick-avoidance and tick-bite prevention measures because no widely available specific antiviral therapy is established for Powassan virus disease. [4]

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