What are the definitions of low‑volume and high‑volume prostate cancer according to the CHAARTED (Chemohormonal Therapy versus Androgen Ablation Randomized Trial for Extensive Disease) criteria?

CHAARTED High-Volume Metastatic Prostate Cancer Definitions

High-volume metastatic prostate cancer (per CHAARTED) is defined as meeting either criterion below. [1], [2]

• Visceral metastases present (non-nodal visceral disease). [1], [2]
• ≥4 bone metastases present, with at least 1 bone metastasis located outside the vertebral column and pelvis (i.e., outside the axial skeleton). [1], [2]

CHAARTED Low-Volume Metastatic Prostate Cancer Definitions

Low-volume metastatic prostate cancer (per CHAARTED) is defined as any metastatic disease that does not meet the high-volume criteria above. [1], [2]