Urine Detection After Discontinuation of SUBLOCADE (Extended-Release Buprenorphine)
SUBLOCADE can remain detectable in urine drug testing for months after the last injection. [1]
Expected Detection Duration in Urine
A pharmacokinetic exposure assessment reported that buprenorphine from SUBLOCADE could potentially be detected in plasma and urine for 22 to 38 months after the last injection. [1]
Urine vs Plasma Detection Differences
Urine concentrations after SUBLOCADE exposure were more variable than plasma concentrations. [1] Buprenorphine is expected to be detected for a longer time in urine than in plasma. [1]
Key Determinants of “Detectable” Status
Detection duration can vary by the test used because urine concentrations depend on the test method employed. [1]
Practical Interpretation for Urine Drug Screens
A negative urine drug screen does not reliably indicate that SUBLOCADE exposure has ended, because buprenorphine may still be detectable for an extended period after discontinuation depending on the assay. [1]