Nexplanon-Related Anxiety and Mood Changes
Nexplanon (etonogestrel implant) has been associated with mood-related adverse reactions, including anxiety, depressed mood, and depression. [1]
Evidence From Prescribing Information
- Depression is listed among reported adverse reactions, including depression leading to discontinuation (2.4% of US subjects, N=330). [1]
- Psychiatric disorders listed in the prescribing information include anxiety and insomnia. [2]
- Depressed mood is included among the labeled adverse reactions. [1]
Clinical Study Findings on Mood and Anxiety Symptoms
- A prospective cohort study of adolescents using the etonogestrel implant reported no statistically significant change in depression, anxiety, or stress symptoms over 3 to 6 months, using validated symptom scales. [3]
Practical Clinical Interpretation of Risk
- Mood symptoms can occur with Nexplanon in some individuals, based on labeled adverse-reaction reporting. [1]
- Average symptom scores in controlled follow-up may remain stable over the first several months in studied populations. [3]
When Further Evaluation Is Indicated
- New or worsening clinically significant mood symptoms (including anxiety and depression) should prompt clinical assessment for other contributing factors and treatment needs. [1]
Key References
- Prescribing information for Nexplanon documents labeled psychiatric adverse reactions and rates of depression leading to discontinuation. [1]
- Prospective cohort data in adolescents found no statistically significant group-level worsening of depression, anxiety, or stress over 6 months. [3]