# Pregnancy & Lactation Safety Lookup (PLLR + LactMed)
> Look up the FDA PLLR narrative + NIH LactMed summary for any medication. Structured trimester + infant-effect framing. Clinical education — verify against the current label.

## Overview

The Pregnancy & Lactation Safety Lookup summarises the FDA Pregnancy and Lactation Labeling Rule (PLLR) narrative and the NIH LactMed entry for a medication. Output is structured by trimester considerations, known fetal risks, data limitations, lactation excretion in breast milk, infant effects, and commonly considered alternatives. Pregnancy and lactation prescribing remains a clinician decision; specialty input (maternal-fetal medicine, teratology specialists, lactation consultants) is commonly appropriate for high-risk situations.

## Who this is for

- Primary care clinicians and APPs
- Obstetric and emergency clinicians
- Pharmacists supporting maternal medication review

## Cited source

**FDA PLLR + NIH LactMed** (2024) — FDA / NIH

_Primary publication:_ FDA PLLR (2015); NIH LactMed (continually updated)

## FAQs

### Does the tool give me a pregnancy category?

No. The PLLR replaced A/B/C/D/X letter categories in 2015 with a narrative summary. The tool reflects the modern narrative format.

### Is LactMed authoritative?

LactMed is the U.S. National Library of Medicine's curated lactation database and is widely considered authoritative for U.S. practice.

### Are there safer alternatives recommended?

When LactMed or PLLR identifies commonly considered alternatives, the tool surfaces them. Always verify against the current LactMed entry.

### When should I refer to MFM or teratology?

High-risk medications (teratogens, complex polypharmacy, first-trimester exposure questions) commonly warrant specialty consultation. The tool flags this in the response.

### Does it cover paternal exposures?

Most pregnancy/lactation guidance focuses on maternal exposure. Paternal-exposure concerns require a different evidence base; consult MotherToBaby or specialty resources.

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_Rounds AI is a citation-first clinical AI assistant. It supports clinical reasoning by surfacing cited information and is not a substitute for independent clinical judgement._