# AI Drug Interaction Checker (Cited)
> Free AI drug-drug interaction checker. Enter two or more medications. Structured severity, mechanism, monitoring, and the FDA label or Lexicomp / Micromedex reference to verify against.

## Overview

The Rounds Drug Interaction Checker takes a list of medications and returns a structured interaction summary for each pair: severity band (contraindicated / major / moderate / minor / not commonly clinically significant), mechanism, clinical effect, monitoring considerations, and the FDA label or commercial reference (Lexicomp, Micromedex) to verify. The tool surfaces the most important pairs for clinician review; severity classifications and monitoring conventions should be confirmed against your institutional pharmacy reference.

## Who this is for

- Hospitalists, primary care clinicians, and APPs reconciling polypharmacy
- Pharmacists performing prescribing reviews
- Medical students learning pharmacokinetics and pharmacodynamics

## Cited source

**FDA Drug-Drug Interaction Labeling Guidance** (2020) — U.S. FDA

_Primary publication:_ Lexicomp / Micromedex commercial DDI databases

## FAQs

### Is this a substitute for Lexicomp or Micromedex?

No. It is a fast first-pass review. Final clinical decisions should be confirmed against an authoritative DDI database your institution has licensed.

### How many medications can I check at once?

The tool accepts up to 15 medications per request to keep responses readable. Larger reconciliations should be done in chunks or with a pharmacist.

### Will it cover supplement interactions?

Yes when well-documented (St John's wort, grapefruit, vitamin K antagonists). For less-studied supplements, the tool flags uncertainty.

### Are pharmacokinetic and pharmacodynamic interactions both surfaced?

Yes — mechanism is included so clinicians can distinguish CYP-mediated, transporter-mediated, and additive pharmacodynamic interactions (QT, serotonin, bleeding).

### Does the severity band determine action?

It supports prioritisation. 'Contraindicated' typically prompts deprescribing; 'major' typically prompts monitoring or alternative agent; 'moderate / minor' commonly informs surveillance. Verify per institutional convention.

---
_Rounds AI is a citation-first clinical AI assistant. It supports clinical reasoning by surfacing cited information and is not a substitute for independent clinical judgement._