Zosyn (piperacillin/tazobactam) IV infusion diluent and IV bag volume
Zosyn should be reconstituted using a labeled compatible reconstitution diluent, then further diluted into a compatible IV solution for infusion. [1]
Compatible reconstitution diluents (powder to solution)
Zosyn vials should be reconstituted with one of the following compatible reconstitution diluents: [1]
- 0.9% sodium chloride for injection. [1]
- Sterile water for injection. [1]
- Dextrose 5%. [1]
- Bacteriostatic saline/parabens. [1]
- Bacteriostatic water/parabens. [1]
- Bacteriostatic saline/benzyl alcohol. [1]
- Bacteriostatic water/benzyl alcohol. [1]
Compatible IV solutions for further dilution (into infusion bag)
The reconstituted Zosyn solution should be further diluted in a compatible intravenous solution that matches the bag/infusion fluid. [1]
Compatible intravenous solutions include: [1]
- 0.9% sodium chloride for injection. [1]
- Sterile water for injection (maximum recommended volume per dose of sterile water is 50 mL). [1]
- Dextran 6% in saline. [1]
- Dextrose 5%. [1]
- Lactated Ringer’s Solution (compatible only with reformulated Zosyn containing EDTA). [1]
Appropriate IV bag size (final diluted dose volume)
For adult and pediatric patients weighing over 40 kg, further dilution should use a recommended volume per dose of 50 mL to 150 mL in an appropriately sized IV bag. [1]
For these doses, the IV bag selection should be based on accommodating the ordered final volume within 50–150 mL. [1]