Discontinuation of Auvelity (dextromethorphan/bupropion)
Discontinuation of AUVELITY should be managed by the prescribing clinician. Stopping AUVELITY suddenly is stated to be associated with serious side effects. [1]
Medication Discontinuation Procedure
- AUVELITY should not be stopped without discussing the discontinuation plan with the healthcare provider. [1]
- AUVELITY can be discontinued due to clinical reasons such as adverse reactions or lack of efficacy per clinical judgment. [1]
- If discontinuation is needed, medication changes should be directed by the healthcare provider rather than performed by the patient. [1]
Abrupt Discontinuation Risk
- Stopping AUVELITY suddenly is stated to possibly cause serious side effects. [1]
Switching to or from a Monoamine Oxidase Inhibitor (MAOI)
- At least 14 days must elapse between discontinuation of an MAOI intended to treat depression and initiation of AUVELITY. [1]
- At least 14 days must be allowed after stopping AUVELITY before starting an MAOI antidepressant. [1]
Co-medication Changes Around Discontinuation
- Starting or stopping other medications during AUVELITY treatment should occur only after discussion with the healthcare provider. [1]
Safety Monitoring After Discontinuation
- Patients should be monitored for recurrence of depression symptoms and for adverse effects related to medication change per clinical follow-up after discontinuation. [1]
Key Clinical Counseling Points
- AUVELITY dosing and regimen changes should be performed only under healthcare provider direction, including changes related to stopping treatment. [1]