Transition from Concerta to JORNAY PM
Concerta should be discontinued when switching to JORNAY PM, and JORNAY PM should be titrated using the JORNAY PM titration schedule. [1] JORNAY PM must not be substituted for other methylphenidate products on a milligram-per-milligram basis because methylphenidate pharmacokinetic profiles differ across products. [1]
Switching Procedure
- Discontinue Concerta before starting JORNAY PM. [1]
- Initiate JORNAY PM at the labeled starting dose in the evening. [1]
- Titrate JORNAY PM weekly based on tolerability and efficacy. [1]
Medication Selection Algorithm
- When switching from other methylphenidate products, JORNAY PM should be selected as the replacement methylphenidate product with no direct milligram-per-milligram conversion. [1]
Initiation Thresholds and Dosing Start
- The recommended starting dosage of JORNAY PM in patients aged 6 years and older is 20 mg once daily in the evening. [1]
- JORNAY PM should not be taken in the morning. [1]
- Dose titration should occur weekly in increments of 20 mg. [1]
Administration Timing During Transition
- JORNAY PM dosing should be initiated at 8:00 p.m. [1]
- Administration timing may be adjusted between 6:30 p.m. and 9:30 p.m. to optimize tolerability and efficacy the next morning and throughout the day. [1]
- After determining the optimal administration time, that time should be maintained consistently. [1]
Common Pitfalls to Avoid
- Direct milligram-per-milligram substitution from Concerta to JORNAY PM should be avoided. [1]
Targets of Therapy During Transition
- JORNAY PM should be titrated to an optimal balance of tolerability and efficacy based on weekly reassessment. [1]