Pregabalin Dosing for Moderate-to-Severe Restless Legs Syndrome in Adults
Pregabalin is recommended for adults with RLS (Strong recommendation, moderate certainty of evidence). [1]
Recommended Dose Range
Clinical trials in adults with moderate-to-severe idiopathic RLS have evaluated pregabalin doses from 50 mg/day to 450 mg/day. [2]
Typical Target Dose Used in Efficacy Trials
A commonly used studied target dose is 300 mg/day. [2]
Dosing Schedule
In a pregabalin RLS dose-response trial, 300 mg/day was administered as a single daily dose 1–3 hours before bedtime. [3]
Dose Individualization and Dose Escalation
Pregabalin dose escalation has been studied across the trial dose range (50 mg/day, 100 mg/day, 150 mg/day, 300 mg/day, and 450 mg/day), supporting titration toward efficacy and tolerability within that range. [2]