Bupropion XL (Wellbutrin XL) Dosage Titration Increment in Adults
The recommended starting dose for major depressive disorder (MDD) is 150 mg once daily in the morning. After 4 days of dosing, the dose may be increased to 300 mg once daily in the morning. [1]
Titration Increment Amount
The titration increment is 150 mg once daily (150 mg once daily to 300 mg once daily). [1]
First Dose Timing
The dose increase is permitted after 4 days of the 150 mg once-daily regimen. [1]
Target Dose After Titration
The target dose after titration for MDD is 300 mg once daily in the morning. [1]
Seasonal Affective Disorder Titration Increment
For seasonal affective disorder (SAD), the starting dose is 150 mg once daily, and the dose may be increased to 300 mg once daily after 7 days. [1]
Important Dose-Related Constraint
Wellbutrin XL is administered once daily in the morning. [1]