What is the incidence (percentage) of Stevens‑Johnson syndrome induced by lamotrigine?

Medical Advisory Board
All articles are reviewed for accuracy by our Medical Advisory Board.

Educational purpose only · Not a substitute for professional judgment or the full text of guidelines and labels.

Article Review Status

Submitted

Under Review

Approved

Last updated: July 14, 2026 · View editorial policy

Stevens-Johnson syndrome incidence with lamotrigine

The incidence of Stevens–Johnson syndrome (SJS) reported from lamotrigine clinical-trial data is age-dependent.

Adults: SJS reported as 0.1% in clinical trials (presented as “possible Stevens–Johnson syndrome”). [1]
Pediatric patients: SJS reported as 0.5% in clinical trials (presented as “possible Stevens–Johnson syndrome”). [1]

Pediatric patients (2–17 years): incidence of serious rash (including SJS) is 0.3% to 0.8%. [2]
Adults: incidence of serious rash (including SJS) is 0.08% to 0.3%. [2]