Pediatric Ondansetron (Zofran) Dosing
Ondansetron pediatric dosing depends on the indication and formulation. [1][2][3][4]
Acute Gastroenteritis With Vomiting (Support With Oral Rehydration)
- Weight-based single dose: 0.15 mg/kg by mouth (liquid/oral formulation), maximum 8 mg per dose. [3]
- Some pediatric emergency/clinical pathways use an oral weight-band regimen that results in the same practical upper limit (example: 8 mg for >30 kg). [4]
Chemotherapy-Induced Nausea and Vomiting (CINV) Prevention
Intravenous or Intramuscular Dosing (Ondansetron Injection)
- For pediatric patients 6 months through 18 years: 0.15 mg/kg per dose IV/IM given 3 doses, with a maximum of 16 mg per dose. [1]
Postoperative Nausea and Vomiting (Pediatric Surgical Patients)
Intravenous Dosing (Ondansetron Injection)
- For pediatric surgical patients 1 month to 12 years: single 0.1 mg/kg IV dose for patients weighing 40 kg or less, or single 4 mg IV dose for patients weighing more than 40 kg. [2]
Formulation Notes
- Dosing above varies by route (oral vs IV/IM) and product concentration. [1][2][3][4]
- Oral disintegrating tablet product labeling includes age-based dosing for certain indications, which may not match gastroenteritis weight-based dosing. [5]
Safety Considerations Common in Pediatric Use
- Ondansetron is used to facilitate tolerance of oral rehydration in pediatric gastroenteritis when vomiting is preventing adequate oral intake. [6]