Contrave (naltrexone/bupropion) Starting Dose for Weight Loss
CONTRAVE should be initiated at 1 tablet (8 mg naltrexone / 90 mg bupropion) taken in the morning with no evening dose during Week 1. [1]
Dose Escalation Schedule
- Week 1: 1 tablet in the morning, evening dose none. [1]
- Week 2: 1 tablet in the morning and 1 tablet in the evening. [1]
- Week 3: 2 tablets in the morning and 1 tablet in the evening. [1]
- Week 4 and onward: 2 tablets in the morning and 2 tablets in the evening. [1]
Practical Administration Constraints
- CONTRAVE tablets should not be cut, chewed, or crushed. [1]
- CONTRAVE should not be taken with a high-fat meal because of increased systemic exposure. [1]
Postural Orthostatic Tachycardia Syndrome Considerations
No POTS-specific dose adjustment is described in the CONTRAVE prescribing information. [1]