In an elderly hypertensive woman on hydralazine who now presents with a skin rash, arthritis, and a pericardial friction rub, which antibody is diagnostic? | Rounds In an elderly hypertensive woman on hydralazine who now presents with a skin rash, arthritis, and a pericardial friction rub, which antibody is diagnostic? | Rounds

In an elderly hypertensive woman on hydralazine who now presents with a skin rash, arthritis, and a pericardial friction rub, which antibody is diagnostic?

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Hydralazine-Induced Lupus Diagnostic Antibody

In hydralazine-induced lupus presenting with rash, arthritis, and serositis, the diagnostic antibody is anti-histone antibodies. [1], [3]

Sources (2)

[1] Research 2025
A Delayed Adverse Reaction: Hydralazine-Induced Lupus After…
Cureus
View Source
[3] Research 2025
A Tale of Overlapping Autoimmune Serologies: Diagnosing Hyd…
Cureus
View Source

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