Rexulti (brexpiprazole) Tablet Splitting
Rexulti (brexpiprazole) tablets are labeled for oral administration once daily. [2] If tablet-splitting instructions are not present in the prescribing information, splitting has not been evaluated for equal dosing between halves. [1]
FDA Guidance on Tablet Splitting
FDA guidance states that tablet splitting should be discussed with a healthcare professional. [1] FDA guidance states that when splitting is not included in the product labeling, FDA has not evaluated whether split halves have the same drug content or deliver the same effect as an intact tablet. [1]
Rexulti Labeling and Administration Instructions
The Rexulti prescribing information provides dosage and administration instructions for oral once-daily administration. [2] The Rexulti prescribing information (as available in the DailyMed label) does not provide instructions endorsing tablet splitting. [2]
Clinical Recommendation on Cutting in Half
Tablet splitting of Rexulti should not be performed unless a prescriber or pharmacist provides specific instructions for that patient and dosing need. [1] Rexulti dosing changes should be handled through available tablet strengths or through an explicitly prescribed alternative strategy rather than unsupervised splitting. [1][2]
Practical Alternatives When a Lower Dose Is Needed
Lower doses should be achieved by prescribing the appropriate Rexulti tablet strength or dosing regimen that matches the target dose. [2] When tablet splitting is being considered for dose adjustment, medication labeling-based dosing should be confirmed with the prescribing clinician or dispensing pharmacist. [1][2]
When Immediate Clarification Is Needed
If a tablet has already been split or accidentally cut, the situation should be confirmed with a pharmacist or the prescriber before the next dose. [1]
Safety Considerations
Inaccurate dosing from unsupervised splitting is a potential concern when labeling does not confirm that halves are equivalent. [1]
Summary of Action
Splitting Rexulti tablets should be avoided unless explicitly directed by a prescriber or pharmacist. [1][2]