Systemic lupus erythematosus–associated flushing
Systemic lupus erythematosus (SLE) can be associated with facial flushing through cutaneous lupus erythema. [1] Facial flushing and burning have been reported in patients with SLE involving chronic facial erythema/rosacea-like skin manifestations. [1]
Skin manifestations that can present as flushing
SLE skin activity can present with visible facial erythema that may be perceived as flushing. [1] In at least one reported case, facial flushing occurred in the setting of an SLE diagnosis and chronic erythema. [1]
Clinical considerations
SLE-associated flushing is typically linked to cutaneous symptoms such as facial erythema and burning rather than isolated episodic hot flashes. [1] Other causes of flushing can coexist with SLE and may require evaluation when symptoms are atypical or progressive.
When urgent evaluation is indicated
Urgent evaluation is indicated for flushing accompanied by breathing difficulty, lip or tongue swelling, syncope, or severe allergic-type symptoms.
Practical next steps for attribution
Assessment for active cutaneous lupus features during symptomatic episodes supports SLE as a contributor. [1] Medication changes near symptom onset can also be relevant when flushing occurs during lupus treatment.